0 7 Soluble soluble JJ 8 15 factors factor NNS 16 24 secreted secrete VBN 25 27 by by IN 28 37 activated activate VBN 38 51 T-lymphocytes t-lymphocyte NNS 52 60 modulate modulate VBP 61 64 the the DT 65 78 transcription transcription NN 79 81 of of IN 82 85 the the DT 86 103 immunosuppressive immunosuppressive JJ 104 112 cytokine cytokine NN 113 121 TGF-beta TGF-beta NNP 122 123 2 2 CD 124 126 in in IN 127 132 glial glial JJ 133 138 cells cell NNS 138 139 . . . 141 153 Coordination coordination NN 154 156 of of IN 157 160 the the DT 161 167 immune immune JJ 168 176 response response NN 177 179 to to TO 180 186 injury injury NN 187 189 or or CC 190 197 disease disease NN 198 200 in in IN 201 204 the the DT 205 210 brain brain NN 211 213 is be VBZ 214 224 postulated postulate VBN 225 227 to to TO 228 235 involve involve VB 236 250 bi-directional bi-directional JJ 251 260 discourse discourse NN 261 268 between between IN 269 272 the the DT 273 279 immune immune JJ 280 286 system system NN 287 290 and and CC 291 294 the the DT 295 302 central central JJ 303 310 nervous nervous JJ 311 317 system system NN 317 318 . . . 319 323 This this DT 324 329 cross cross JJ 330 343 communication communication NN 344 352 involves involve VBZ 353 360 soluble soluble JJ 361 370 mediators mediator NNS 370 371 , , , 372 381 including include VBG 382 389 various various JJ 390 396 growth growth NN 397 404 factors factor NNS 404 405 , , , 406 415 cytokines cytokine NNS 415 416 , , , 417 420 and and CC 421 434 neuropeptides neuropeptide NNS 434 435 . . . 436 438 In in IN 439 443 this this DT 444 450 report report NN 450 451 , , , 452 454 we we PRP 455 466 demonstrate demonstrate VBP 467 471 that that IN 472 475 the the DT 476 487 supernatant supernatant NN 488 492 from from IN 493 502 activated activate VBN 503 516 T-lymphocytes t-lymphocyte NNS 517 519 is be VBZ 520 524 able able JJ 525 527 to to TO 528 534 induce induce VB 535 538 the the DT 539 552 transcription transcription NN 553 555 of of IN 556 557 a a DT 558 564 potent potent JJ 565 573 cytokine cytokine NN 573 574 , , , 575 583 TGF-beta TGF-beta NNP 584 585 2 2 CD 586 588 in in IN 589 594 glial glial JJ 595 600 cells cell NNS 600 601 . . . 602 605 The the DT 606 616 activating activate VBG 617 625 stimulus stimulus NN 626 633 invokes invoke VBZ 634 643 signaling signaling NN 644 654 mechanisms mechanism NNS 655 663 distinct distinct JJ 664 668 from from IN 669 674 known known JJ 675 681 kinase kinase NNP 682 684 or or CC 685 693 protease protease NN 694 702 pathways pathway NNS 702 703 . . . 704 714 Activation Activation NNP 715 717 of of IN 718 726 TGF-beta TGF-beta NNP 727 728 2 2 CD 729 742 transcription transcription NN 743 753 correlates correlate VBZ 754 758 with with IN 759 762 the the DT 763 767 loss loss NN 768 770 of of IN 771 778 binding binding NN 779 787 activity activity NN 788 791 for for IN 792 794 an an DT 795 797 80 80 CD 798 801 kDA kda NN 802 807 glial glial JJ 808 814 labile labile JJ 815 824 repressor repressor NN 825 832 protein protein NN 832 833 , , , 834 838 GLRP GLRP NNP 838 839 , , , 840 842 to to TO 843 844 a a DT 845 855 responsive responsive JJ 856 862 region region NN 863 869 within within IN 870 873 the the DT 874 882 TFG-beta TFG-beta NNP 883 884 2 2 CD 885 893 promoter promoter NN 893 894 . . . 895 903 Although although IN 904 908 GLRP GLRP NNP 909 915 shares share NNS 916 920 some some DT 921 936 characteristics characteristic NNS 937 941 with with IN 942 945 the the DT 946 955 inducible inducible JJ 956 969 transcription transcription NN 970 976 factor factor NN 977 981 AP-1 ap-1 NN 981 982 , , , 983 985 it it PRP 986 993 appears appear VBZ 994 996 to to TO 997 999 be be VB 1000 1008 distinct distinct JJ 1009 1013 from from IN 1014 1019 known known JJ 1020 1024 AP-1 ap-1 NN 1025 1031 family family NN 1032 1039 members member NNS 1039 1040 . . . 1041 1046 These these DT 1047 1051 data datum NNS 1052 1057 along along IN 1058 1062 with with IN 1063 1071 previous previous JJ 1072 1084 observations observation NNS 1085 1098 demonstrating demonstrate VBG 1099 1102 the the DT 1103 1109 potent potent JJ 1110 1127 immunosuppressive immunosuppressive JJ 1128 1136 activity activity NN 1137 1139 of of IN 1140 1148 TGF-beta TGF-beta NNP 1149 1150 2 2 CD 1150 1151 , , , 1152 1159 support support VBP 1160 1161 a a DT 1162 1167 model model NN 1168 1171 for for IN 1172 1173 a a DT 1174 1182 feedback feedback NN 1183 1192 mechanism mechanism NN 1193 1200 between between IN 1201 1204 the the DT 1205 1214 activated activate VBN 1215 1228 T-lymphocytes t-lymphocyte NNS 1229 1232 and and CC 1233 1243 astrocytes astrocyte NNS 1244 1247 via via IN 1248 1256 TGF-beta TGF-beta NNP 1257 1258 2 2 CD 1259 1261 to to TO 1262 1270 regulate regulate VB 1271 1274 the the DT 1275 1281 immune immune JJ 1282 1290 response response NN 1290 1291 . . .