0 12 Epstein-Barr epstein-barr JJ 13 18 virus virus NN 19 26 binding bind VBG 27 29 to to TO 30 34 CD21 CD21 NNP 35 44 activates activate VBZ 45 48 the the DT 49 56 initial initial JJ 57 62 viral viral JJ 63 71 promoter promoter NN 72 75 via via IN 76 85 NF-kappaB NF-kappaB NNP 86 95 induction induction NN 95 96 . . . 98 110 Epstein-Barr epstein-barr JJ 111 116 virus virus NN 117 118 ( ( ( 118 121 EBV EBV NNP 121 122 ) ) ) 122 123 , , , 124 126 an an DT 127 136 oncogenic oncogenic JJ 137 142 human human JJ 143 154 herpesvirus herpesvirus NN 154 155 , , , 156 161 binds bind VBZ 162 164 to to TO 165 168 and and CC 169 176 infects infect VBZ 177 183 normal normal JJ 184 189 human human JJ 190 191 B b NN 192 203 lymphocytes lymphocyte NNS 204 207 via via IN 208 212 CD21 CD21 NNP 212 213 , , , 214 217 the the DT 218 221 CR2 cr2 NN 222 232 complement complement NN 233 241 receptor receptor NN 241 242 . . . 243 250 Studies study NNS 251 253 of of IN 254 257 the the DT 258 268 mechanisms mechanism NNS 269 273 that that WDT 274 280 enable enable VBP 281 284 EBV EBV NNP 285 287 to to TO 288 294 infect infect VB 295 307 nonactivated nonactivated JJ 307 308 , , , 309 319 noncycling noncycling JJ 320 321 B B NNP 322 327 cells cell NNS 328 335 provide provide VBP 336 346 compelling compelling JJ 347 355 evidence evidence NN 356 359 for for IN 360 361 a a DT 362 370 sequence sequence NN 371 373 of of IN 374 380 events event NNS 381 383 in in IN 384 389 which which WDT 390 393 EBV EBV NNP 394 401 binding bind VBG 402 404 to to TO 405 409 CD21 cd21 NN 410 412 on on IN 413 421 purified purify VBN 422 429 resting rest VBG 430 435 human human JJ 436 437 B B NNP 438 443 cells cell NNS 444 451 rapidly rapidly RB 452 461 activates activate VBZ 462 465 the the DT 466 475 NF-kappaB NF-kappaB NNP 476 489 transcription transcription NN 490 496 factor factor NN 496 497 , , , 498 503 which which WDT 503 504 , , , 505 507 in in IN 508 512 turn turn NN 512 513 , , , 514 519 binds bind VBZ 520 522 to to TO 523 526 and and CC 527 535 mediates mediate VBZ 536 551 transcriptional transcriptional JJ 552 562 activation activation NN 563 565 of of IN 566 568 Wp Wp NNP 568 569 , , , 570 573 the the DT 574 581 initial initial JJ 582 587 viral viral JJ 588 594 latent latent JJ 595 599 gene gene NN 600 608 promoter promoter NN 608 609 . . . 610 614 Thus thus RB 614 615 , , , 616 619 EBV EBV NNP 620 627 binding bind VBG 628 630 to to TO 631 634 its its PRP$ 635 643 cellular cellular JJ 644 652 receptor receptor NN 653 655 on on IN 656 663 resting rest VBG 664 665 B B NNP 666 671 cells cell NNS 672 680 triggers trigger VBZ 681 683 an an DT 684 703 NF-kappaB-dependent nf-kappab-dependent JJ 704 717 intracellular intracellular JJ 718 727 signaling signaling NN 728 735 pathway pathway NN 736 741 which which WDT 742 744 is be VBZ 745 753 required require VBN 754 757 for for IN 758 767 infection infection NN 767 768 . . .